1-Methylpiperazine → N-[3-methoxy-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Reaction equation

[CH3:1][S:2]([O:3][CH2:6][CH2:7][O:8][c:9]1[n:10][nH:11][c:12]2[n:13][cH:14][n:15][c:16]([NH:18][c:19]3[cH:20][c:21]([O:33][CH3:34])[c:22]([O:25][CH2:26][c:27]4[n:28][cH:29][cH:30][cH:31][cH:32]4)[cH:23][cH:24]3)[c:17]12)(=[O:4])=[O:5].[CH3:35][N:36]1[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]1>>[CH2:6]([CH2:7][O:8][c:9]1[n:10][nH:11][c:12]2[n:13][cH:14][n:15][c:16]([NH:18][c:19]3[cH:20][c:21]([O:33][CH3:34])[c:22]([O:25][CH2:26][c:27]4[n:28][cH:29][cH:30][cH:31][cH:32]4)[cH:23][cH:24]3)[c:17]12)[N:39]1[CH2:38][CH2:37][N:36]([CH3:35])[CH2:41][CH2:40]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 115114392-[(4-{[3-methoxy-4-(pyridin-2-ylmethoxy)phenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethyl methanesulfonate

Product 1

HCID 11656116N-[3-methoxy-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record: ord-f7d249ce485148acac5207c264cf2009
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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