1H-1,2,4-Triazole → 1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole
Reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9](Cl)=[O:10]>C(OCC)(=O)C>[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.
Workup
- stirringThe mixture was stirred for 30 min
- filtrationfiltered
- customThe residue obtained
- customafter evaporation of the solvent
- dissolutionwas redissolved in dichloromethane (25 mL)
- filtrationfiltered
- customEvaporation of the solvent
Sources & evidence
- ORD record
- ord-0c18d3271e484f0f9ae2b826de5610c7
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723470
Reaction notes
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