Dichloromethane → N-butan-2-yl-3-(piperazin-1-ylmethyl)benzamide

Reaction equation

[CH:1]([CH3:2])([CH2:3][CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][c:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]2)[cH:25][cH:26][cH:27]1.[Cl:35][CH2:36][Cl:37].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[CH:1]([CH3:2])([CH2:3][CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][c:10]([CH2:11][N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[cH:25][cH:26][cH:27]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 66878539Tert-butyl 4-[[3-(butan-2-ylcarbamoyl)phenyl]methyl]piperazine-1-carboxylate

Product 1

HCID 66878608N-butan-2-yl-3-(piperazin-1-ylmethyl)benzamide

Sources & evidence

ORD record: ord-212a6d723aa043b28d42a7aa9ef82c30
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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