Acetic Acid → 5-Bromo-2-(3-chloro-4-fluorobenzyl)-8-hydroxy-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione

Reaction equation

[Br:1][c:2]1[c:3]2[c:8]([c:9]([O:13][CH3:14])[c:10](=[O:12])[nH:11]1)[C:7](=[O:15])[N:6]([CH2:16][c:17]1[cH:18][c:19]([Cl:24])[c:20]([F:23])[cH:21][cH:22]1)[CH2:5][CH2:4]2.[BrH:25].[CH3:26][C:27](=[O:28])[OH:29]>>[Br:1][c:2]1[c:3]2[c:8]([c:9]([OH:13])[c:10](=[O:12])[nH:11]1)[C:7](=[O:15])[N:6]([CH2:16][c:17]1[cH:18][c:19]([Cl:24])[c:20]([F:23])[cH:21][cH:22]1)[CH2:5][CH2:4]2

Participants

Reactant 3

HCID 176Acetic Acid

HCID 260Hydrogen Bromide

HCID 690618815-Bromo-2-(3-chloro-4-fluorobenzyl)-8-methoxy-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione

Product 1

HCID 546986315-Bromo-2-(3-chloro-4-fluorobenzyl)-8-hydroxy-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione

Sources & evidence

ORD record: ord-30defc38b93b42838f22be8e8adb84cc
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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