Chloride → 5-Bromo-6-methoxy-1-indanone

HRID 950509Notes

Reaction equation

HRID 950509 reaction equation
[Al+3:20].[Br:1][c:2]1[cH:3][c:4]([CH2:10][CH2:11][C:12](=[O:13])[OH:14])[cH:5][cH:6][c:7]1[O:8][CH3:9].[Cl-:19].[Cl-:21].[Cl-:22].[OH2:23].[S:15]([Cl:16])([Cl:17])=[O:18]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][c:7]1[O:8][CH3:9])[C:12](=[O:14])[CH2:11][CH2:10]2

Participants

6

Reactant 5

HCID 312Chloride3×HCID 962WaterHCID 24386Thionyl ChlorideHCID 104727Aluminum CationHCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid

Product 1

HCID 222787185-Bromo-6-methoxy-1-indanone

Sources & evidence

ORD record
ord-755c2b88ea2143e3a70aa18999640ee7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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