Dichloromethane → Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

HRID 950868Notes

Reaction equation

HRID 950868 reaction equation
[CH2:34]([Cl:35])[Cl:36].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7].[c:8]1(-[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:9][cH:10][c:11]([CH2:14][CH:15]([C:16](=[O:17])[O:18][CH3:19])[NH:20][C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[cH:12][cH:13]1>>[c:8]1(-[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:9][cH:10][c:11]([CH2:14][CH:15]([C:16](=[O:17])[O:18][CH3:19])[NH2:20])[cH:12][cH:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 2736832Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate

Product 1

HCID 21830061Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

Sources & evidence

ORD record
ord-12d26de0f283443aba88f21d62f7bf9e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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