Water → N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-6-(trifluoromethyl)nicotinamide

Reaction equation

[CH3:26][N:27]1[CH2:28][CH2:29][CH2:30][C:31]1=[O:32].[Cl:1][c:2]1[cH:3][c:4]([NH2:12])[n:5][c:6]2[n:7]1[n:8][c:9]([CH3:11])[cH:10]2.[F:13][C:14]([c:15]1[n:16][cH:17][c:18]([C:19](=[O:20])[Cl:21])[cH:22][cH:23]1)([F:24])[F:25].[OH2:33]>>[Cl:1][c:2]1[cH:3][c:4]([NH:12][C:19]([c:18]2[cH:17][n:16][c:15]([C:14]([F:13])([F:24])[F:25])[cH:23][cH:22]2)=[O:20])[n:5][c:6]2[n:7]1[n:8][c:9]([CH3:11])[cH:10]2