Indole → 3-chloro-propane-1-sulfonic acid [2-(1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-methyl-amide

HRID 952103

Reaction equation

HRID 952103 reaction equation
[BH:27]([OH:28])[OH:29].[Cl:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]([S:13](=[O:14])(=[O:15])[CH2:16][CH2:17][CH2:18][Cl:19])[CH3:20])[s:10]2.[nH:30]1[cH:31][cH:32][c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]12>>[c:2]1(-[c:34]2[c:33]3[cH:32][cH:31][nH:30][c:38]3[cH:37][cH:36][cH:35]2)[n:3][c:4]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]([S:13](=[O:14])(=[O:15])[CH2:16][CH2:17][CH2:18][Cl:19])[CH3:20])[s:10]2

Participants

4

Reactant 3

HCID 798IndoleHCID 61668Boronic AcidHCID 86618405HCID 86618405, compound

Product 1

HCID 671900123-chloro-propane-1-sulfonic acid [2-(1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-methyl-amide

Sources & evidence

ORD record
ord-cce8460331604ea9be9362335ea6f059
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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