Acetate → 5-(4-(4-Methoxybenzylamino)-5-nitropyridin-2-ylamino)pyrazine-2-carbonitrile

HRID 952163

Reaction equation

HRID 952163 reaction equation
[CH3:17][C:18]([CH3:19])([O-:20])[CH3:21].[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH3:23][O:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][NH:30][c:31]2[cH:32][c:33]([Br:40])[n:34][cH:35][c:36]2[N+:37](=[O:38])[O-:39])[cH:41][cH:42]1.[NH2:8][c:9]1[n:10][cH:11][c:12]([C:15]#[N:16])[n:13][cH:14]1.[Na+:22].[O-:44][C:45]([CH3:46])=[O:47].[O-:48][C:49]([CH3:50])=[O:51].[O:52]=[CH:53][N:54]([CH3:55])[CH3:56].[Pd+2:43]>>[NH:8]([c:9]1[n:10][cH:11][c:12]([C:15]#[N:16])[n:13][cH:14]1)[c:33]1[cH:32][c:31]([NH:30][CH2:29][c:28]2[cH:27][cH:26][c:25]([O:24][CH3:23])[cH:42][cH:41]2)[c:36]([N+:37](=[O:38])[O-:39])[cH:35][n:34]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 923Sodium ionHCID 1140TolueneHCID 6228DimethylformamideHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 45749132-Methylpropan-2-olateHCID 139252945-Aminopyrazine-2-carbonitrileHCID 56926468N-(4-Methoxybenzyl)-2-bromo-5-nitropyridin-4-amine

Product 1

HCID 670174595-(4-(4-Methoxybenzylamino)-5-nitropyridin-2-ylamino)pyrazine-2-carbonitrile

Sources & evidence

ORD record
ord-ad2a9f3095a74972b2858bd9c7a553e5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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