Phosphorus oxybromide → 2-Bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Reaction equation

[CH3:1][c:2]1[cH:3][c:4](-[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]2)[cH:5][c:6](=[O:8])[nH:7]1.[P:19]([Br:20])([Br:21])([Br:22])=[O:23]>>[CH3:1][c:2]1[cH:3][c:4](-[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]2)[cH:5][c:6]([Br:21])[n:7]1

Participants

Reactant 2

HCID 24613Phosphorus oxybromide

HCID 574686446-Methyl-4-(4-(trifluoromethyl)phenyl)pyridin-2-OL

Product 1

HCID 574686462-Bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Sources & evidence

ORD record: ord-868225e8ecd94a8495bf34838e5524ca
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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