4-Chlorobutyryl chloride → 5-(4-Chlorobutyrylamino)-2,3,4,5-tetrahydro-1-benzoxepine
Reaction equation
[NH2:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH2:4][CH2:3]1.[Cl:13][CH2:14][CH2:15][CH2:16][C:17](Cl)=[O:18]>>[Cl:13][CH2:14][CH2:15][CH2:16][C:17]([NH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH2:4][CH2:3]1)=[O:18]Participants
3
Procedure
5-amino-2,3,4,5-tetrahydro-1-benzoxepine and 4-chlorobutyryl choride were used to produce the above compound in the same way as Reference Example 8.
Workup
- customto produce the above compound in the same way as Reference Example 8
Sources & evidence
- ORD record
- ord-b9bc34feae494fc2941a6a9edafd74d8
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723475
Reaction notes
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