Tetrahydrofuran → 8-Tert-butyl-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid-(3-fluoro-4-methanesulphonylaminophenyl)amide

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][C:8]2([CH2:9][C:10]([C:13](=[O:14])[OH:15])=[N:11][O:12]2)[CH2:16][CH2:17]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[NH2:18][c:19]1[cH:20][c:21]([F:30])[c:22]([NH:25][S:26](=[O:27])(=[O:28])[CH3:29])[cH:23][cH:24]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][C:8]2([CH2:9][C:10]([C:13](=[O:15])[NH:18][c:19]3[cH:20][c:21]([F:30])[c:22]([NH:25][S:26](=[O:27])(=[O:28])[CH3:29])[cH:23][cH:24]3)=[N:11][O:12]2)[CH2:16][CH2:17]1