Dichloromethane → 3-[[3,3-Dimethyl-1-oxo-1-(1-phenylethylamino)butan-2-yl]carbamoyl]-6-(3-methyl-4-phenoxyphenyl)hexanoic acid

HRID 955932

Reaction equation

[CH3:8][C:9]([CH:10]([C:11](=[O:12])[NH:13][CH:14]([CH3:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[NH:22][C:23](=[O:24])[CH:25]([CH2:26][C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:34][CH2:35][CH2:36][c:37]1[cH:38][c:39]([CH3:50])[c:40]([O:43][c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:41][cH:42]1)([CH3:51])[CH3:52].[Cl:53][CH2:54][Cl:55].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[CH3:8][C:9]([CH:10]([C:11](=[O:12])[NH:13][CH:14]([CH3:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[NH:22][C:23](=[O:24])[CH:25]([CH2:26][C:27](=[O:28])[OH:29])[CH2:34][CH2:35][CH2:36][c:37]1[cH:38][c:39]([CH3:50])[c:40]([O:43][c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:41][cH:42]1)([CH3:51])[CH3:52]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 22950117Tert-butyl 3-[[3,3-dimethyl-1-oxo-1-(1-phenylethylamino)butan-2-yl]carbamoyl]-6-(3-methyl-4-phenoxyphenyl)hexanoate

Product 1

HCID 98939883-[[3,3-Dimethyl-1-oxo-1-(1-phenylethylamino)butan-2-yl]carbamoyl]-6-(3-methyl-4-phenoxyphenyl)hexanoic acid

Sources & evidence

ORD record: ord-dbeeada83eb2450e8c36f2ccd1d652e8
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Linked notes

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