Dichloromethane → 4-Methyl-4-(2-trifluoromethylphenoxy)piperidine
Reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([O:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)([CH3:25])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:33][CH2:34][Cl:35].[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[NH:8]1[CH2:9][CH2:10][C:11]([O:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)([CH3:25])[CH2:12][CH2:13]1Participants
4
Sources & evidence
- ORD record
- ord-c22aedcdbaf349bcb3e6296dba68c1ba
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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