N,N-Dimethylaniline → 2-Chloro-5-isopropylpyrimidine

Reaction equation

[CH3:16][N:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH3:24].[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][n:6][c:7](=[O:10])[nH:8][cH:9]1.[P:11]([Cl:12])([Cl:13])([Cl:14])=[O:15]>>[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][n:6][c:7]([Cl:13])[n:8][cH:9]1

Participants

Reactant 3

HCID 949N,N-Dimethylaniline

HCID 24813Phosphorus oxychloride

HCID 123561535-Isopropylpyrimidin-2(1H)-one

Product 1

HCID 198466722-Chloro-5-isopropylpyrimidine

Sources & evidence

ORD record: ord-d74e4098d4814ec5ba8ad4386084f877
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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