Diisopropylamine → (4-tert-Butoxy-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile

HRID 960334

Reaction equation

HRID 960334 reaction equation
[C:19]([CH3:20])([CH3:21])([CH3:22])[O:23][c:24]1[c:25]([O:32][CH3:33])[c:26]([F:31])[n:27][cH:28][c:29]1[F:30].[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH:13]1([CH2:16][C:17]#[N:18])[CH2:14][CH2:15]1.[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[CH:13]1([CH:16]([C:17]#[N:18])[c:26]2[c:25]([O:32][CH3:33])[c:24]([O:23][C:19]([CH3:20])([CH3:21])[CH3:22])[c:29]([F:30])[cH:28][n:27]2)[CH2:14][CH2:15]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 643447CyclopropylacetonitrileHCID 225603574-tert-Butoxy-2,5-difluoro-3-methoxypyridineHCID 178418339Butyllithium

Product 1

HCID 10707715(4-tert-Butoxy-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile

Sources & evidence

ORD record
ord-7a31d10c303c48679043681c37cfb3b2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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