Bromide ion → (4-Chloro-6-fluoroquinazolin-2-yl)(4-fluorophenyl)methanone
Reaction equation
[Br-:18].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cl:1][c:2]1[n:3][c:4]([C:13]([O:15][CH2:14][CH3:16])=[O:17])[n:5][c:6]2[cH:7][cH:8][c:9]([F:12])[cH:10][c:11]12.[F:19][c:20]1[cH:21][cH:22][c:23]([Mg+:26])[cH:24][cH:25]1>>[Cl:1][c:2]1[n:3][c:4]([C:13](=[O:15])[c:23]2[cH:22][cH:21][c:20]([F:19])[cH:25][cH:24]2)[n:5][c:6]2[cH:7][cH:8][c:9]([F:12])[cH:10][c:11]12Participants
5
Sources & evidence
- ORD record
- ord-874dce46916d457184d27eaeb771e4d9
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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