1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 3-Dimethylamino-1-(4-trifluoromethyl-phenyl)-but-2-en-1-one
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1.CO[C:16]([N:20]([CH3:22])[CH3:21])(OC)[CH3:17]>C(OCC)C>[CH3:21][N:20]([CH3:22])[C:16]([CH3:17])=[CH:10][C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:12])([F:13])[F:1])=[CH:8][CH:7]=1)=[O:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 112 °C
Procedure
A mixture of 4′-(trifluoromethyl)acetophenone (9.8 g) and N-(1,1-dimethoxyethyl)-N,N-dimethylamine (8.2 g) was heated at 112° C. overnight, under nitrogen. The reaction mixture was cooled and concentrated giving an orange solid. Trituration with diethyl ether gave the title compound as a yellow solid