Oxalyl chloride → 2,2-Dimethyl-4-benzyloxycarbonylbutyryl chloride

HRID 964194

Reaction equation

HRID 964194 reaction equation
[CH3:1][C:2]([CH3:18])([CH2:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:22])=O>>[CH3:1][C:2]([CH3:18])([CH2:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[C:3]([Cl:22])=[O:4]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 190800452,2-Dimethyl-4-benzyloxycarbonylbutyric acid

Product 1

HCID 190800382,2-Dimethyl-4-benzyloxycarbonylbutyryl chloride

Procedure

A mixture of 3.1 g of 2,2-dimethyl-4-benzyloxycarbonylbutyric acid and 3.3 ml of oxalyl chloride was refuxed for 1 h. After being cooled to room temperature, the solution was concentrated in vacuo and dried overnight The obtained oil was not further purified for the next reaction.

Workup

  1. concentrationthe solution was concentrated in vacuo
  2. customdried overnight The obtained oil
  3. customwas not further purified for the next reaction

Sources & evidence

ORD record
ord-3e46a729568240518792c9616546daaf
Source dataset
uspto-grants-1998_06
Patent number
US05767256

Linked notes

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