Hydrochloric Acid → 4-(5-chloro-2-oxo-4-(piperidin-4-yloxy)pyridin-1(2H)-yl)-2-fluorobenzonitrile

Reaction equation

[CH3:33][OH:34].[Cl:1][c:2]1[c:3]([O:18][CH:19]2[CH2:20][CH2:21][N:22]([C:25]([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[CH2:23][CH2:24]2)[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:14]#[N:15])[cH:12][cH:13]2)[cH:7]1.[ClH:32]>>[Cl:1][c:2]1[c:3]([O:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:14]#[N:15])[cH:12][cH:13]2)[cH:7]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 57468467Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Product 1

HCID 673687134-(5-chloro-2-oxo-4-(piperidin-4-yloxy)pyridin-1(2H)-yl)-2-fluorobenzonitrile

Sources & evidence

ORD record: ord-a628673f5b364fb79a85c88e066a74c4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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