Perchloric Acid → HCID 22116111, compound
Reaction equation
[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=O)[C:5]1=[O:14].Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
1-(2-Chloroethyl)-lH-indol-2,3-dione (5.24 g) [C.A. Reg no. 77218-99-6] was suspended in acetic acid (50 ml) and hydrogenated at 60 p.s.i., at room temperature, in the presence of 70% perchloric acid (0.2 ml) and 5% palladium on charcoal (1 g) for 24 hours. The clear solution was filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluent chloroform, to give 1-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one as a white solid.
Workup
- filtrationThe clear solution was filtered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by chromatography on silica gel, eluent chloroform
Sources & evidence
- ORD record
- ord-e50f9d551456438196f57063bd6952ee
- Source dataset
- uspto-grants-1998_06
- Patent number
- US05773448
Reaction notes
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