Chlorosulfonic acid → Ethyl 2-(4-(chlorosulfonyl)-2-ethylphenoxy)acetate

HRID 9671

Reaction equation

HRID 9671 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH3:14])[CH3:2].[Cl:16][S:17](O)(=[O:19])=[O:18]>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:9][C:8]=1[CH2:13][CH3:14])[CH3:2]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 21986411Ethyl (2-ethylphenoxy)acetate2×

Product 1

HCID 21986343Ethyl 2-(4-(chlorosulfonyl)-2-ethylphenoxy)acetate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of crude ethyl(2-ethylphenoxy)acetate (intermediate 107) in chloroform (6 ml) was stirred with chlorosulfonic acid (1.33 ml) at ambient temperature for 4 hours. The reaction mixture was quenched by the addition of ice and the organic mixture separated by using a hydrophobic frit. The title compound was isolated by evaporation of this filtrate.

Workup

  1. customThe reaction mixture was quenched by the addition of ice
  2. customthe organic mixture separated

Sources & evidence

ORD record
ord-1f39594965174048aec2d27ed501f246
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

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