Reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[S:4][C:3]=1[CH:17]=[O:18].FC(F)(F)C1C=CC(C2C=C(C(O)=[O:33])SC=2)=CC=1>>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:11][CH:12]=2)[S:4][C:3]=1[C:17]([OH:33])=[O:18]Participants
3
Procedure
The title compound was prepared using 3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehyde (intermediate 74) by a method analogous to the preparation of 4-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylic acid (intermediate 38).
Sources & evidence
- ORD record
- ord-b32d3278f4144988a796a1120977547e
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07091237B2
Linked notes
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