Methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate → {3-{[(2-Isopropyl-6-methylpyrimidin-4-yl)oxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

HRID 9685

Reaction equation

HRID 9685 reaction equation
Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[S:5][C:4]=1[C:18](OC)=[O:19].[CH:22]([C:25]1[N:30]=[C:29]([OH:31])[CH:28]=[C:27]([CH3:32])[N:26]=1)([CH3:24])[CH3:23]>>[CH:22]([C:25]1[N:30]=[C:29]([O:31][CH2:2][C:3]2[CH:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=3)[S:5][C:4]=2[CH2:18][OH:19])[CH:28]=[C:27]([CH3:32])[N:26]=1)([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 21986302Methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate2×HCID 178419104HCID 178419104, compound

Product 1

HCID 21986496{3-{[(2-Isopropyl-6-methylpyrimidin-4-yl)oxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

Procedure

The title compound was prepared using methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate (intermediate 132) and 2-isopropyl-6-methyl-4-pyrimidinol.

Sources & evidence

ORD record
ord-af55f1b94a2548bbb8c81307374898be
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

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