Hydrochloric Acid → (3R)-thiomorpholine-3-carboxylic acid methyl ester hydrochloride
Reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][S:9][CH2:8][CH2:7][NH:6]1)=[O:4].[ClH:11]>CCOCC.C(O)C>[ClH:11].[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][S:9][CH2:8][CH2:7][NH:6]1)=[O:4]Participants
5
Procedure
10.9 g of (3R)-thiomorpholine-3-carboxylic acid methyl ester was dissolved in 150 mL of ether and 90 mL 14.5% of hydrogen chloride dissolved in ethanol was added dropwise in the above solution to obtain 13.0 g of (3R)-thiomorpholine-3-carboxylic acid methyl ester hydrochloride as a white solid. Yield 97.2%□mp 160-161° C.
Workup
- additionwas added dropwise in the above solution
Sources & evidence
- ORD record
- ord-43df5b0db3a84be49789c6be86763655
- Source dataset
- uspto-grants-2007_12
- Patent number
- US07304057B2
Reaction notes
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