Azane;hydrate → Imidazo(1,2-a)pyrazin-8-amine, 6-bromo-
Reaction equation
[Br:1][C:2]1[N:3]=[C:4](Br)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[NH3:12].O>CN>[NH2:12][C:4]1[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=[C:2]([Br:1])[N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 85 °C
Procedure
Procedure 1: A mixture of 1.00 eq. of 6,8-imidazo[1,2-a]pyrazine 3 in 28% Ammonia/water solution or 40% aqueous methyl amine is heated to between 80 to 90° C. for 24 hr. The resulting mixture is partitioned between CH2Cl2 and H2O. The aqueous layer is extracted with CH2Cl2 and the combined organic extracts are dried over Na2SO4. The solvent is removed under reduced pressure and the resulting residue is crystallized from ethanol to yield 4.
Workup
- customThe resulting mixture is partitioned between CH2Cl2 and H2O
- extractionThe aqueous layer is extracted with CH2Cl2
- dry with materialthe combined organic extracts are dried over Na2SO4
- customThe solvent is removed under reduced pressure
- customthe resulting residue is crystallized from ethanol
- customto yield 4
Sources & evidence
- ORD record
- ord-db0df8c76d4641c1b92ee750881dd855
- Source dataset
- uspto-grants-2007_12
- Patent number
- US07312341B2
Reaction notes
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