HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Potassium Hydroxide → Ethylene glycol bis[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propyl]ether

HRID 972030
Notes
Print preview

Reaction equation

HRID 972030 reaction equation
[CH3:1][C:2]1([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:17]1[CH2:28][CH:18]1[CH2:19][O:20][CH2:21][CH2:22][O:23][CH2:24][CH:25]1[O:27][CH2:26]1.[OH-:29].[K+]>CO>[OH:17][CH:18]([CH2:28][N:6]1[C:5](=[O:29])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:19][O:20][CH2:21][CH2:22][O:23][CH2:24][CH:25]([OH:27])[CH2:26][N:6]1[C:5](=[O:10])[C:4]2([CH2:3][C:2]([CH3:16])([CH3:1])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 16683Glycol diglycidyl etherHCID 12680667,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Product 1

HCID 131711586Ethylene glycol bis[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propyl]ether

Reagents, catalysts & solvents 1

HCID 887Methanol
Solvent

Procedure

A mixture of 7.7 g of 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 2.5 g of ethylene glycol bis(2,3-epoxypropyl)ether and 0.1 g of potassium hydroxide in 80 ml of methanol was refluxed for 11 hours. Insoluble materials were then filtered off and the filtrate was washed with hot methanol. The solution was dried and then the solvent evaporated off. The residue was recrystallised from N,N-dimethylformamide, giving the desired compound in the form of white crystals, melting at 262°-264° C.

Workup

  1. temperaturewas refluxed for 11 hours
  2. filtrationInsoluble materials were then filtered off
  3. washthe filtrate was washed with hot methanol
  4. customThe solution was dried
  5. customthe solvent evaporated off
  6. customThe residue was recrystallised from N,N-dimethylformamide

Sources & evidence

ORD record
ord-8cdc1f6f705c4407b4c0af05e71bd929
Source dataset
uspto-grants-1979_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04162246

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes