Hydroxylamine → HCID 21406762, compound

Reaction equation

[NH2:1][OH:2].[F:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11](Cl)=[O:12])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]>CCOCC.O>[F:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11]([NH:1][OH:2])=[O:12])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]

Participants

Procedure

Hydroxylamine free base was added to a solution of 2,2',4'-trifluoro-4-biphenylylacetyl chloride (obtained as in Example 9) in ether. After stirring for 15 minutes the ether solution was diluted with water, separated, washed again with water, dried and evaporated. The orange residue was recrystallised twice from acetone/40-60 petroleum ether and then from toluene to give fine colourless needles of 2,2',4'-trifluoro-4-biphenylylacethydroxamic acid, m.p. 149°-150° C.