Ethanol → Benzene, 1,3-dichloro-5-nitro-
Reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[C:5](N)=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.C(O)C.S(=O)(=O)(O)O.N([O-])=O.[Na+]>O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:10]([O-:12])=[O:11])[CH:5]=[C:7]([Cl:9])[CH:8]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
207 parts of 4,6-dichloro-2-nitro-aniline are introduced into 400 parts of ethanol and 900 parts of water, and 400 parts of concentrated sulfuric acid (98 percent strength by weight) are then added to the mixture. A solution of 105 parts of NaNO2 in 175 parts of water is run in at 80° C., as described in Example 1. The mixture is cooled and the product is filtered off. 182 parts (95% of theory) of 3,5-dichloro-nitro-benzene, of melting point 56°-59° C., are obtained.
Workup
- additionare then added to the mixture
- customis run in at 80° C.
- temperatureThe mixture is cooled
- filtrationthe product is filtered off
Sources & evidence
- ORD record
- ord-c9bf08f38efb46f0987d460193911431
- Source dataset
- uspto-grants-1977_10
- Patent number
- US04053527
Reaction notes
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