1-Methylhomopiperazine → 3-Cyano-2-pyridone

HRID 972690

Reaction equation

HRID 972690 reaction equation
FC1C=CC([C:8]2[NH:9][C:10](=[O:16])[C:11](=[CH:14][CH:15]=2)[C:12]#[N:13])=CC=1.CN1CCCNCC1>CS(C)=O>[O:16]=[C:10]1[NH:9][CH:8]=[CH:15][CH:14]=[C:11]1[C:12]#[N:13]

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 27652036-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Product 1

HCID 5775433-Cyano-2-pyridone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

From 12.9 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 13.8 g. of N-methylhomopiperazine in 180 ml. of dimethyl sulfoxide, there is obtained 6-[p-hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]-1,2-dihydro-2-oxonicotinonitrile.

Sources & evidence

ORD record
ord-c243a54c7755405bbe0f6fee84b3a5ed
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Linked notes

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