Aminoethylpiperazine → (3-Chloropropanoyl)urea

HRID 973134

Reaction equation

[NH2:1]CCN1CCNCC1.[Cl:10][CH2:11][CH2:12][C:13]([N:15]=[C:16]=[O:17])=[O:14]>>[Cl:10][CH2:11][CH2:12][C:13]([NH:15][C:16]([NH2:1])=[O:17])=[O:14]

Participants

Reactant 2

HCID 8795Aminoethylpiperazine

HCID 135723743-Chloropropanoyl isocyanate

Product 1

HCID 12937417(3-Chloropropanoyl)ureaYield 263%

Procedure

In the same way, reaction of 6.5 g (50 mmols) of N-(2-aminoethyl)piperazine with 14.3 g (106 mmols) of 3-chloropropionyl isocyanate gives a quantitative yield of 19.8 g of the 3-chloropropionyl urea of the formula ##STR10## Melting point: 125°-130° C.

Sources & evidence

ORD record: ord-1d934c9c935a41dea3f3940d8c0f79b1
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04055431

Linked notes

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