Dimethylformamide → 4-Cyano-2-(3-cyanophenyl)-pyridine

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)[CH:3]=1.[Cu](C#N)[C:16]#[N:17].[CH3:20][N:21](C)C=O>>[C:16]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:20]#[N:21])[CH:9]=2)[CH:3]=1)#[N:17]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 199886504-Chloro-2-(3-bromophenyl)-pyridine

HCID 178418260HCID 178418260, compound

Product 1

HCID 199886564-Cyano-2-(3-cyanophenyl)-pyridine

Procedure

Starting from 4-chloro-2-(3-bromophenyl)-pyridine, the title compound is prepared by reaction with copper cyanide in boiling N,N-dimethylformamide.

Sources & evidence

ORD record: ord-58500937992f497fbdcd8217a91d8ebb
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05064832

Reaction notes

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