Methane → 2-(2,6-Dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime

HRID 973675Notes

Reaction equation

HRID 973675 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][NH2:14].O=[C:16]([CH3:20])[CH:17]=[N:18][OH:19].S([O-])([O-])(=O)=O.[Mg+2].C>CCOCC>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[C:16]([CH3:20])[CH:17]=[N:18][OH:19]

Participants

6

Reactant 4

HCID 297MethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 688223[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazineHCID 63992132-Oxopropanal-1-oxime

Product 1

HCID 1363412052-(2,6-Dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 2,6-dichloro-4-trifluoromethylphenylhydrazine (10.2 g) in ether (15 ml) was added with cooling to a solution of `2-oxopropanal 1-oxime (3.62 g) in ether (15 ml) at 0°. The mixture was stirred at room temperature overnight and magnesium sulphate and charcoal added. The mixture was filtered and solvent evaporated under reduced pressure. The residue was purified by column chromatography to give 2-(2,6-dichloro-4-trifluoromethylphenylhydrazono)propanal 1-oxime, m.p, c.108°.

Workup

  1. filtrationThe mixture was filtered
  2. customsolvent evaporated under reduced pressure
  3. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-f5e3e5b3d37946958d7541f859f44bf7
Source dataset
uspto-grants-1991_11
Patent number
US05064844

Reaction notes

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