Reaction equation
[CH3:1][CH:2]([C:6](O)=O)[C:3]([OH:5])=[O:4].[CH3:9][NH:10][CH3:11].C=O>O>[CH3:9][N:10]([CH3:11])[CH2:6][CH:2]([CH3:1])[C:3]([OH:5])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
In 1.0 ml of water was dissolved 1.5 g of methylmalonic acid, after which 1.26 g of a 50% aqueous dimethylamine solution and 0.96 ml of a 37% aqueous formaldehyde solution were added with stirring at 0° C., and the resulting mixture was stirred at 0° to 5° C. for 3 hours and then at 80° C. for 30 minutes.
Workup
- stirringthe resulting mixture was stirred at 0° to 5° C. for 3 hours
Sources & evidence
- ORD record
- ord-cc3d7a87fd854185b231c67ec2bf855a
- Source dataset
- uspto-grants-1991_11
- Patent number
- US05064945
Linked notes
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