Hydrogen Cyanide → 2-Hydroxy-4-phenylbutanenitrile

HRID 974107Notes

Reaction equation

HRID 974107 reaction equation
[C:1]1([CH2:7][CH2:8][CH:9]=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])(=O)C.[Na+].[CH:16]#[N:17]>>[OH:10][CH:9]([CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:16]#[N:17]

Participants

4

Reactant 3

HCID 768Hydrogen CyanideHCID 7707BenzenepropanalHCID 517045Sodium Acetate

Product 1

HCID 109098692-Hydroxy-4-phenylbutanenitrile

Procedure

In a 300 ml flask, 134 g of 3-phenylpropanal and 1.4 g of 10% aqueous sodium acetate solution were placed, to which 27 g of hydrocyanic acid was added in dropwise maintaining the reaction temperature at 20° to 25° C., thereafter the reaction mixture was kept standing for 30 min.

Workup

  1. additionwas added
  2. temperaturein dropwise maintaining the reaction temperature at 20° to 25° C.

Sources & evidence

ORD record
ord-195888bdc1f94ab2a580c2a60e8b69d5
Source dataset
uspto-grants-1991_11
Patent number
US05066826

Reaction notes

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