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1-(3-Bromopropyl)-4-chlorobenzene → 2-Amino-6-(3-4-chlorophenyl)propyl-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974319
Notes
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Reaction equation

HRID 974319 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]Br)=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1>CN(C)C=O>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:10][CH2:9][CH2:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 98811361-(3-Bromopropyl)-4-chlorobenzeneHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine

Product 1

HCID 199858162-Amino-6-(3-4-chlorophenyl)propyl-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepineYield 37%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared from 3-(4-chlorophenyl)propyl bromide and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in anhydrous dimethylformamide. Yield: 37% of theory, Melting point: 153° C.

Sources & evidence

ORD record
ord-474f57415d6b48e091e29a814c157049
Source dataset
uspto-grants-1991_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05068325

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes