3-Bromothiophene → 1-(2,5-Dimethyl-4-oxazolyl)-1-(3-thienyl)ethanol

HRID 975057

Reaction equation

Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[C:7]([C:10]1[N:11]=[C:12]([CH3:16])[O:13][C:14]=1[CH3:15])(=[O:9])[CH3:8]>>[CH3:16][C:12]1[O:13][C:14]([CH3:15])=[C:10]([C:7]([C:2]2[CH:6]=[CH:5][S:4][CH:3]=2)([OH:9])[CH3:8])[N:11]=1

Participants

Reactant 2

HCID 133833-Bromothiophene

HCID 147385831-(2,5-Dimethyl-1,3-oxazol-4-yl)ethan-1-one

Product 1

HCID 189363261-(2,5-Dimethyl-4-oxazolyl)-1-(3-thienyl)ethanol

Procedure

Starting with 3-bromothiophene and 4-acetyl-2,5dimethyloxazole and following the general method of Example 4 the title compound was prepared. M.p. 83°-84° C.

Sources & evidence

ORD record: ord-bb8c48182fd645bb8d418cce532ec93c
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05607956

Linked notes

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