Hydrochloric Acid → HCID 22376950, compound
Reaction equation
C(OC([NH:8][CH:9]([P:17]([CH:22]([NH:30]C(OC(C)(C)C)=O)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:21])[O:18]CC)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.CO.C1(C)C=CC=CC=1.[ClH:47]>>[ClH:47].[NH2:8][CH:9]([P:17]([CH:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:18])[OH:21])[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1Participants
5
Procedure
A solution of the bisalkylated phosphinic acid ester 10 (170 mg, 0.32 mmol) in 37% aqueous hydrochloric acid (20 ml) is heated to a temperature of about 100° C. for 6 hours. After concentration of the reaction solution under reduced pressure and repeated coevaporation with methanol and toluene, the phosphinic acid hydrochloride 16 (101 mg, 93% of theory) is obtained.