Trifluoroacetic acid → (Benzyloxy)(methyl)amine

HRID 976632

Reaction equation

C(O[C:6](=O)[N:7]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)CC(C)C)(C)(C)C.C(ON(C)C(=O)OC(C)(C)C)C1C=CC=CC=1.FC(F)(F)C(O)=O>>[CH2:13]([O:12][NH:7][CH3:6])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 14227181tert-butyl N-benzyloxy-N-methylcarbamate

HCID 19967428tert-butyl N-benzyloxy-N-(2-methylpropyl)carbamate

Product 1

HCID 13417387(Benzyloxy)(methyl)amine

Procedure

Using the general method of Compound 54 Part C, tert-butyl N-benzyloxy-N-methylcarbamate (3.0 g, 13 mmol) was reacted with trifluoroacetic acid (10 mL, 130 mmol) to provide 1.58 g of N-benzyloxy-N-methylamine as a yellow oil.

Sources & evidence

ORD record: ord-dfca262cc7444a829f0c340430c1b57e
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05612377

Linked notes

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