Methanol → 6-(3,5-Difluorophenyl)-4-hydroxy-3,3-dimethylpiperidin-2-one
Reaction equation
[BH4-:19].[CH2:21]1[O:22][CH2:23][CH2:24][CH2:25]1.[CH3:26][OH:27].[F:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][C:11](=[O:18])[C:12]([CH3:16])([CH3:17])[C:13](=[O:15])[NH:14]2)[cH:5][c:6]([F:8])[cH:7]1.[Na+:20]>>[F:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][CH:11]([OH:18])[C:12]([CH3:16])([CH3:17])[C:13](=[O:15])[NH:14]2)[cH:5][c:6]([F:8])[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-5c7108793e794964bb4c0a5c20b0b87b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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