Hydrochloric Acid → HCID 178447643, compound
Reaction equation
Cl.[CH3:2][N:3]1[C:7]([CH:8]([CH3:15])[CH2:9][CH2:10][C:11]([O:13]C)=[S:12])=[N:6][N:5]=[N:4]1>O>[CH3:2][N:3]1[C:7]([CH:8]([CH3:15])[CH2:9][CH2:10][C:11]([OH:13])=[S:12])=[N:6][N:5]=[N:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
20% aqueous Hydrochloric acid (150 ml) is added to methyl 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiovalerate (17 g) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with chloroform. The chlorofom solution is washed with aqueous saturated sodium chloride solution and dried over magnesium sulfate. Chloroform is distilled off to give 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-valeric acid, colorless liquid, nD26 =1.5133.
Workup
- temperaturethe mixture is refluxed for 2 hours
- temperatureAfter cooling
- extractionextracted with chloroform
- washThe chlorofom solution is washed with aqueous saturated sodium chloride solution
- dry with materialdried over magnesium sulfate
- distillationChloroform is distilled off
Sources & evidence
- ORD record
- ord-66a854a61ef94e1db8cb2e85e07aefe9
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04663323
Reaction notes
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