Ethylenediamine → [2-(2-Aminoethyl)amino-5-nitrophenyl]-benzyl sulphone
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[S:11]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:13])=[O:12].[NH2:21][CH2:22][CH2:23][NH2:24]>C(O)(C)C>[NH2:21][CH2:22][CH2:23][NH:24][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[S:11]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:13])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
16.0 g of benzyl 2-chloro-5-nitrophenyl sulphone and 12.0 g of 1,2-diaminoethane are refluxed in 100 ml of isopropanol for one hour. The reaction mixture is cooled down, and the solids are filtered off with suction, are washed with 50 ml of water and are dried. This gives 19.2 g of pale yellow [2-(2-aminoethyl)-amino-5-nitrophenyl]-benzyl sulphone.