Potassium Carbonate → HCID 15069997, compound
Reaction equation
[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
13 g (65 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux in 300 ml of water with 41 g of Ba(OH)2.8H2O overnight. Potassium carbonate is added, the barium carbonate which has precipitated out is filtered off with suction and the filtrate is extracted ten times with 100 ml of chloroform each time. The extract is dried over potassium carbonate and concentrated and the residue is distilled.
Workup
- customthe barium carbonate which has precipitated out
- filtrationis filtered off with suction
- extractionthe filtrate is extracted ten times with 100 ml of chloroform each time
- dry with materialThe extract is dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-1cd424f1b1fc4ca3ad6e526726fa1146
- Source dataset
- uspto-grants-1991_02
- Patent number
- US04990517
Reaction notes
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