Trifluoroacetic anhydride → HCID 20071767, compound
Reaction equation
[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:18])[CH:11]([CH3:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:6][CH:5]=1)=O.[F:19][C:20]([F:31])([F:30])[C:21]([O:23]C(=O)C(F)(F)F)=[O:22]>>[F:19][C:20]([F:31])([F:30])[C:21]([O:23][CH2:1][S:2][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:18])[CH:11]([CH3:17])[CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:6][CH:5]=1)=[O:22]Participants
3
Procedure
A solution of the sulfoxide from Step C of this Example (10 g) in trifluoroacetic anhydride (50 ml) was heated at 45° C. for 25 minutes and the mixture was evaporated, and then coevaporated with toluene, to dryness to give the title compound as an oil (15 g, crude) which was used directly in the following step.
Workup
- customwas heated at 45° C. for 25 minutes
- customthe mixture was evaporated
Sources & evidence
- ORD record
- ord-6676e588402743eda18ec160fd86ddfa