Isobutylbenzene → 4'-Isobutylacetophenone

HRID 981373

Reaction equation

HRID 981373 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[C:11](F)(=[O:13])[CH3:12]>CC(O)=O>[CH3:3][CH:2]([CH2:1][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:12])=[O:13])=[CH:7][CH:6]=1)[CH3:4]

Participants

4

Reactant 2

HCID 10870IsobutylbenzeneHCID 11204Acetyl fluoride

Product 1

HCID 932144'-Isobutylacetophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Isobutylbenzene (IBB) (10.2 lb/hr) and a solution of HF containing 13 wt % HOAc and 12 wt % acetyl fluoride (AcF) (153 lb/hr) were fed into reactor 1 through line 4. The mixture was reacted at 60° C. for 1.5 hrs to produce the desired 4-isobutylacetophenone product.

Workup

  1. customwere fed into reactor
  2. customThe mixture was reacted at 60° C. for 1.5 hrs

Sources & evidence

ORD record
ord-d3b93062aae846dd972c13f70c9a7b8b
Source dataset
uspto-grants-1991_02
Patent number
US04990681

Linked notes

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