CO[CH:3](OC)[CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[C:11]([F:13])[C:10]([O:14][CH3:15])=[C:9]([F:16])[CH:8]=1.[S-:19][C:20]#[N:21].[K+].Cl>C(O)C.O>[F:16][C:9]1[CH:8]=[C:7]([CH:12]=[C:11]([F:13])[C:10]=1[O:14][CH3:15])[CH2:6][N:5]1[CH:4]=[CH:3][N:21]=[C:20]1[SH:19]
To a solution of N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal (4.94 g, 0.0189 mole) in ethyl alcohol (30 ml) was added potassium thiocyanate (2.10 g, 0.0216 mole) in water (48 ml) followed by 12 N hydrochloric acid (4 ml), and the reaction mixture was heated under reflux for 3.5 hours. The solvent was partially removed under reduced pressure, the mixture was cooled in ice, and the product was filtered. The product was recrystallized from ethyl alcohol - hexane to give 1-(3,5-difluoro-4-methoxybenzyl)-2-mercaptoimidazole as a solid melting at 160-161° (2.22 g, 46%).
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