1-[4-[(4-Fluorophenyl)methyl]phenyl]piperazine → 5-[2-(4-(4-(4-Fluorophenyl)methylphenyl)piperazin-1-yl)acetyl]-2,3,4,5-tetrahydro-1,5-benzoxazepine

HRID 982

Reaction equation

HRID 982 reaction equation
Br[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[F:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)=[CH:26][CH:25]=2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH2:31][CH2:32][N:33]([CH2:2][C:3]([N:5]4[C:11]5[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=5[O:9][CH2:8][CH2:7][CH2:6]4)=[O:4])[CH2:34][CH2:35]3)=[CH:26][CH:25]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 15199981-[4-[(4-Fluorophenyl)methyl]phenyl]piperazineHCID 196942555-(2-Bromoacetyl)-2,3,4,5-tetrahydro-1,5-benzoxazepine

Product 1

HCID 196942525-[2-(4-(4-(4-Fluorophenyl)methylphenyl)piperazin-1-yl)acetyl]-2,3,4,5-tetrahydro-1,5-benzoxazepine

Procedure

The compound (15) synthesized in Reference Example and the compound (5) synthesized in Reference Example were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-29980035cd8743d88cbb26a64e2988b5
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Linked notes

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