Methyl 3-amino-2-thiophenecarboxylate → HCID 178437764, compound

HRID 982140

Reaction equation

HRID 982140 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9]C)=O.[C:11](N)(=[NH:14])[CH2:12][CH3:13]>>[CH2:12]([C:11]1[N:14]=[C:7]([OH:9])[C:3]2[S:4][CH:5]=[CH:6][C:2]=2[N:1]=1)[CH3:13]

Participants

3

Reactant 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 415117Propionamidine hydrochloride

Product 1

HCID 178437764HCID 178437764, compound

Conditions

Temperature
60 °C

Procedure

Methyl 3-amino-2-thiophenecarboxylate (4.67 g,) and propionamidine (3 g, were combined and heated in an oil both for 1/2 hour at 60° C.; 1/2 hour at 80° C.; 1/2 hour at 100° C. and finally for 4 hours at 120° C. The mixture was cooled, triturated with ether, filtered and washed with ether to obtain 0.67 g of the product; m.p. 233°-237° C.

Workup

  1. custom1/2 hour
  2. customat 80° C.
  3. temperatureThe mixture was cooled
  4. customtriturated with ether
  5. filtrationfiltered
  6. washwashed with ether

Sources & evidence

ORD record
ord-b46f55dfb744492280886387eb3267fb
Source dataset
uspto-grants-1991_02
Patent number
US04994464

Linked notes

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