Water → 5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-chloro-5H-pyrrolo[3,2-d]pyrimidine

HRID 98258

Reaction equation

[Br:17][CH2:18][CH2:19][CH2:20][O:21][Si:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[CH3:28].[C:11](=[O:12])([O-:13])[O-:14].[CH3:29][N:30]([CH3:31])[CH:32]=[O:33].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][cH:9][nH:10]2.[Cs+:15].[Cs+:16].[OH2:34]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][cH:9][n:10]2[CH2:18][CH2:19][CH2:20][O:21][Si:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[CH3:28]

Participants

Reactant 6

HCID 962Water

HCID 6228Dimethylformamide

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 607486(3-Bromopropoxy)(tert-butyl)dimethylsilane

HCID 53706954-chloro-5H-pyrrolo[3,2-d]pyrimidine

Product 1

HCID 866157565-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-chloro-5H-pyrrolo[3,2-d]pyrimidine

Sources & evidence

ORD record: ord-27c783d9c5bc4f9d8385d4968356f3f2
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Linked notes

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