Methanol → N-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-4-fluoro-benzamide

HRID 98516

Reaction equation

HRID 98516 reaction equation
[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:31][OH:32].[F:21][c:22]1[cH:23][cH:24][c:25]([C:26](=[O:27])[Cl:28])[cH:29][cH:30]1.[NH2:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[C:6](=[O:11])[N:5]([CH:12]1[C:13](=[O:19])[NH:14][C:15](=[O:18])[CH2:16][CH2:17]1)[C:4]2=[O:20]>>[NH:1]([c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[C:6](=[O:11])[N:5]([CH:12]1[C:13](=[O:19])[NH:14][C:15](=[O:18])[CH2:16][CH2:17]1)[C:4]2=[O:20])[C:26]([c:25]1[cH:24][cH:23][c:22]([F:21])[cH:30][cH:29]1)=[O:27]

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 678794-Fluorobenzoyl chlorideHCID 134780Pomalidomide

Product 1

HCID 10222298N-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-4-fluoro-benzamide

Sources & evidence

ORD record
ord-ea288fce2c73498f888a702aaddfa226
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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